Mom Who Lost Three Children in Tragic Car Crash and Later Welcomed Triplets Passes Away at 48 After Brain Cancer Battle

Her husband, who took fans along throughout her journey to the end, has confirmed the devastating news no one wanted to hear. Keep reading to see his heartwrenching updates in the days leading to her death.

Lori Coble, an extraordinary woman who endured unimaginable heartbreak and still managed to touch countless lives along the way, has died at just 48 years old.

And in a gut-wrenching post that left followers reeling, her husband Chris Coble revealed the moment their world shattered once again. "Lori passed at 9:25pm this evening," Chris wrote on social media Wednesday night, 21 January 2026.

Lori died surrounded by her family after a brutal battle with brain cancer, bringing to a tragic close a life marked by both deep joy and devastating loss.

Because for Lori, pain was not something that simply visited once.

Back in 2007, she suffered a tragedy so horrific it still stops people in their tracks: she lost all three of her children in a car accident — Kyle Christopher, 5, Emma Lynn, 4, and Katie Gene, 2.

The grief nearly swallowed the couple whole.

But after months of struggling to survive the unthinkable, Lori and Chris made a decision that would change the course of their lives: they tried to have children again.

And just one year after losing their little ones, fate handed them something almost impossible to believe — Lori became pregnant with triplets.

In a quiet tribute that carried enormous weight, each of their three children was given an older sibling's middle name: Jake Christopher, Ashley Lynn, Ellie Gene.

For the next 16 years, the Cobles poured everything into raising their family — which is why Lori's death now feels like a fresh, agonizing blow not just for her loved ones, but for the many strangers who watched her story unfold in real time.

After Chris shared his heartbreaking update, messages of love and grief flooded his timeline almost instantly.

"Oh no Chris. I am so sorry. The only saving grace is she is no longer suffering and she is with her babies. I wish you some comfort and peace in this difficult time. Love and prayers for you and your family," one person wrote.

"Chris, my heart aches with yours. It's not fair…hasn't been since 2007. You've been a rock thru this whole journey and once again set an example of what true love looks like. I know you know this… but your beautiful wife is truly a difference maker in our world," another offered.

"May her soul rest in peace... I have been following her story, she's with her 3 angels now," a third consoled.

"I will never forget you guys. Your courage, strength, and love amid challenges no one should ever have to deal with.. Lori's life and legacy and impact stretches far and wide," a fourth shared.

And one message cut especially deep for those who had been watching Chris post update after update through the darkest days.

"Oh Chris, and the whole family, we are so incredibly sorry for this immense loss. [...] Thank you for being strong enough to post continual updates while also being the most wonderful husband, father, and friend," someone else posted.

Even after she regained strength, the road ahead only grew more punishing.

Lori was diagnosed with a large and aggressive stage 4 glioblastoma in July 2025, after Chris noticed something was wrong the month before. In an interview with People, Chris described the terrifying changes that seemed to come out of nowhere.

His wife began getting clumsy, running into walls, stubbing her toes, and dropping drinking glasses to the floor. But in early July, the warning signs turned even more alarming when Chris saw what looked like stroke symptoms.

"Her mouth started to droop a little bit," he recalled. "It became too much to ignore." When the diagnosis came back, Chris said he couldn't believe they were being dragged into yet another nightmare.

"I was hoping we were done with the life-changing, life-altering disasters where life as you knew it yesterday is gone," he admitted. "I started mourning the loss of my wife the day she got diagnosed."

In the months that followed, Lori underwent two surgeries to remove the tumor. The second operation was said to have been invasive and complex — and it left her with loss of control on her left side.

Days later, she suffered a stroke and was placed into a medically induced coma. Even after she regained strength, the road ahead only grew more punishing.

Lori returned home to begin chemotherapy and radiation, but the treatment took a brutal toll. She became increasingly exhausted, and her speech was affected. Loved ones feared she was worsening before their eyes.

By mid-November, Chris rushed her to the emergency room, where doctors discovered something else had gone terribly wrong: Lori had developed a large infection in her brain.

Yet again, she would need surgery.

By early December, Lori was brought home for hospice care — as her family prepared to say goodbye. It was an especially painful time for the couple's three children, now in their senior year of high school, as they faced life without their mother.

Through it all, those closest to Lori wanted only one thing: for her to be comfortable in her final days. A GoFundMe has since been established to assist her family.

Scroll down to see Chris' heartwrenching updates about Lori's condition in the days before she died.

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