Rosie O'Donnell, 63, Stuns with 'Phenomenal' Weight-Loss Results in New Pic

The 63-year-old actress revealed she now wears a size 12 and credited Mounjaro for helping her transformation, sparking a wave of praise across social media.

Rosie O'Donnell recently shared a full-body photo of herself on Instagram, and her slimmed-down physique had everybody talking. The comedian and actress stunned fans with her transformation as comments quickly poured in about her new look.

On August 13, 2025, O'Donnell posted a snapshot taken inside a dressing room while shopping for a loungewear outfit ahead of her upcoming 22-hour flight to Australia.

Dressed in a black zip-up jacket and matching pants, she stood against a bright yellow wall and revealed in her caption that she was "shocked" to now be a size 12, crediting Mounjaro as "a life saver [sic]."

The post drew an immediate reaction from followers. One wrote, "She looks much smaller than size 12," while another added, "You're so tiny! You look amazing!"

Another netizen chimed in, "Rosie you look the healthiest I've ever seen you. So proud of your accomplishment [sic]," while a fourth wrote, "You look Phenomenal!!❤️"

Other fans marveled at her beauty, while others repeated that O'Donnell looked even smaller than a size 12. One person recalled appearing as an extra in "A League of Their Own" and shared their longtime support for the actress, while another summed it up simply by saying they were deeply impressed.

This is not the first time the Hollywood star has turned heads with her weight-loss transformation in recent months.

The actress made a striking appearance on the red carpet at the London premiere of "Burlesque: The Musical" on Tuesday, July 22, where the 63-year-old comedian and TV personality wore a coordinated gray and black pantsuit featuring bold, graffiti-style artwork inspired by New York City.

The outfit included a gray blazer printed with repeated "New York" text and a large red apple across the chest. Her black pants echoed the urban design, decorated with stars and sketch-like drawings.

She finished the look with a black T-shirt, black boots, and her signature glasses. O'Donnell's noticeably slimmer frame drew attention, reigniting public interest in her weight loss journey.

The transformation has been partially attributed to Mounjaro, a diabetes medication also known for its weight-loss effects. Fans responded quickly to her red carpet appearance, with many commenting on her new look.

"Lovin' the outfit! @rosie lookin' so slim n vibzzy! ❤️," wrote one person. Another added, "You look wonderful! I start Mounjaro next week! Thank you for your testimony! 🥰"

O'Donnell previously shared on TikTok in March that she had been prescribed the drug for diabetes and acknowledged its impact on her weight.

"I've lost more weight. I am on Mounjaro for my diabetes, and one of the side effects is you lose weight," she said in the video. She also noted lifestyle changes, including the absence of a personal chef, as factors contributing to the shift. "It's me cooking for Clay and me," she added, referring to her son.

The comedian added that the changes have been surprising, "I'm one of those people who always had a weight issue, and now that I'm a size large — instead of an XL or a XXL — I find it shocking. I really do. I find it completely shocking."

Her latest public appearance has added to ongoing conversations around health, body image, and the growing use of medications like Mounjaro in the entertainment industry.

Speculation around O'Donnell's weight loss began long before her recent red carpet appearance.

In 2023, she addressed the growing curiosity from fans through a candid video update. Responding to a comment about her changing appearance, Rosie O'Donnell explained that her doctor had initiated a new treatment plan.

"Okay, so like two months ago, my doctor put me on — not Ozempic — Mounjaro, something like that… I can't even really pronounce it — and Repatha," she said.

She described the routine, noting that one injection is done every other week and the other once a week. The video provided insight into the beginning of her health transformation and confirmed what many had already begun to notice.