Christina Applegate Reveals How Her Illness Influenced Her Daughter Sadie

After being hospitalized and divulging the pain she went through, Christina Applegate discloses her daughter's struggle as the young teen witnesses her mom's battle with devastating MS symptoms.

Hollywood icon Christina Applegate has peeled back the curtain on the silent heartbreak unfolding behind closed doors — revealing how her beloved daughter is crumbling under the weight of watching her ailing mother.

In a soul-baring podcast episode, the "Dead to Me" star opened up about how her brutal battle with multiple sclerosis (MS) has left her young daughter, Sadie Grace LeNoble, emotionally shattered. And her words? Nothing short of devastating.

From a Fit Dancer to a Nearly Immobile Mother: Christina Applegate Breaks Down Her Daughter's Heartbreak

On August 26, 2025, Applegate and fellow actress Jamie-Lynn Sigler sat down for an episode of their podcast, "MeSsy," where Applegate did not hold back.

"Well, of course. And I mean, in my situation, Sadie only knew me as healthy. You know, a runner, a pellotoner, a dancer," she shared in response to Sigler noting how their kids often observe them with a keen eye and worry about them. "So then, when this came about, 2021, [sic] she was like stoic about it." But that stoic shell began to crack.

'I see her look at me when I'm in bed and can't quite move, or I wanna go say goodnight to her in her room, but I can't quite get down the hallway for whatever reason that my legs aren't working that day," she continued, her voice thick with emotion.

"Right now, I can barely get to the bathroom; it's the worst, but that's neither here nor there. But, I just — it's broken her, you know? And she didn't know this."

And it's only getting harder. "It was like losing the mom she had to this [expletive] thing. And the more she's gotten older now, I think the more it's hurting her," Applegate divulged, painting a haunting picture of a teen silently grieving the mother she once knew.

Pandemic Pain, MS Diagnosis — And the Collapse of Childhood Innocence

Applegate's diagnosis came at a time of global upheaval, and the timing couldn't have been worse for LeNoble.

"I was diagnosed in 2021, so we had just gone through COVID and no school, and all this stuff, and now mommy can't do all the things that she used to be able to do. And I see it in her eyes. I see it," Applegate revealed, pointing to the compounded trauma her daughter endured.

But amid the grief, flickers of grace shine through — instances where LeNoble steps into the role of caregiver, and a force of strength and support.

"When we're out, she knows I'm having such a hard time because I have such anxiety about being out, and she's always got my arm. She's always trying to help me through, and help me with my cane, and all this stuff," Applegate disclosed, describing a new kind of bond — one born of resilience and love.

Still, the light moments between mother and daughter continue — even if they're tinged with the ache of lost normalcy.

"She's like, 'Can you please go down and make my food, 'cause you're the only one who can make it.' She's like, 'You're going down all the steps,'" Applegate recounted with a bittersweet laugh.

Christina Applegate's Fight to Still Be 'Mom'

Despite the agony, the fatigue, and the crippling loss of mobility, Applegate refuses to give in. "And I'm like, 'Sadie! I can't make it down the [expletive] steps!' But I do it. I do it, because I know that it's like — she's like checking in to make sure, 'Can she still take care of me?'" noted the devoted mother.

It's these raw and achingly human moments that have made "MeSsy" a refuge for listeners — a space where Applegate reveals what few stars dare to share.

And this recent episode? A gut-wrenching glimpse into a daughter's pain, a mother's honesty, and the fragile strength that binds them together.

Just weeks earlier, Christina Applegate stunned listeners when she recorded another emotional episode from a hospital bed, sharing the harrowing pain she was enduring after being hospitalized.

The 53-year-old Emmy winner delivered the update in the August 5 episode of "MeSsy." But this time, the recording came not from a studio, but from a hospital room where Applegate was fighting a severe kidney infection.

The ordeal began overseas. While visiting family in Europe, the beloved "Married... With Children" star started experiencing alarming waves of stomach pain.

The Actress Describes Unrelenting Pain That Triggered an Emergency CT Scan

"I was not feeling good the whole time I was there," Applegate explained. "But not like the kind of bad where I had missed days. It would just be like up and down. Like, I'd be okay for a couple hours, and then I'd be having [sic] to go lie down because my stomach was really bad."

The mysterious symptoms worsened dramatically on her 11-hour flight home. Rather than brush it off, Applegate took charge, demanding to be admitted and evaluated immediately after landing.

"I want to be admitted. I'm not listening to you guys. We're — I'm staying here because I want answers. I want every test that you can possibly think of, or ones that you haven't even thought of, and I want them done," she recalled saying, in a defiant stand for her health.

By Sunday, she was in unbearable pain. What started on the right side of her abdomen soon radiated around to her back — a searing, full-body agony that left her initially fearing her appendix may be bursting.

"From my back to my front, is like in [sic] so much pain. I'm like screaming. And they ordered me an emergency CT at two o'clock in the morning," she shared. That scan delivered the shocking truth — she had a kidney infection, which required intravenous antibiotics, that had already spread from one kidney to the other.

The infection, doctors believed, likely started as a urinary tract infection. In classic Applegate fashion, she met the moment with humor — even when medical staff asked an eyebrow-raising question.

She recalled how they questioned if she was "wiping correctly." In response, Applegate laughed off the suggestion and noted that she is meticulous about personal hygiene, joking that she keeps herself "a clean girl down yonder." But behind the laughter lurked concern, as doctors were not ruling out something far more serious.

"And now they're thinking it could be something else, and I don't want to say what they think, um, because I don't want it to sound scary, but, um, I'm just going to be here," she said ominously.

The stay was more than just physically draining. Emotionally, Applegate broke down, relying on nurses for comfort and distracting herself with hospital ice, mindless TV, and what she called "bedrotting" — hours spent simply trying to survive.

Home at Last, but the Battle Isn't Over

After a week of hospital care, Applegate was finally discharged. In an exclusive with People magazine, she confirmed she was recovering at home — but her ongoing stomach issues remain "a work in progress."

Applegate's health struggles are compounded by her battle with MS. MS is an autoimmune condition that affects the brain and spinal cord. In people with the disease, the immune system mistakenly attacks myelin, the protective covering that surrounds nerve fibers.

She has shared how it's affected her ability to eat and drink, noting how drinking through a straw sometimes helps her swallow. Though there's no cure, treatment can slow the disease — but nearly one million Americans live with its exhausting symptoms.

A candid confession came during a 2024 interview on Good Morning America, when Applegate called MS "the invisible disease." On a November 2024 "MeSsy" episode, she revealed, "I lay in bed screaming."

Christina Applegate Faces Acting Uncertainty

The relentless pain and intense muscle spasms have driven her to stay home, cancel outings, and question her future in the very industry that made her a star. In 2023, Applegate received her star on the Hollywood Walk of Fame — a bittersweet moment that she dubbed "my beginning and my… my possible end."

She also said the final season of "Dead to Me" holds a special place in her heart. However, it took extraordinary accommodations to film it.

From needing a sound tech to physically hold her legs steady during standing scenes to constant monitoring on set, Applegate's pain was ever-present. Yet her appreciation for the production team was profound.

"We don't know what my future as an actress is going to be," she said. "How can I handle it? How can I go onto a set and call the shots of what I need as far as my boundaries, physically? I don't know who is going to be as loving and understanding as this group of people were [sic]."